Greenville is located in Mississippi's Delta Region on Highway 1 at the highest point on the Mississippi River between Vicksburg and Memphis. The Greenville airport serves the Mississippi Delta Region. Greenville is significant in Mississippi's blues history. Historic Nelson Street features a strip of blues clubs that was a hot spot for Delta blues, jump blues, jazz and big band music in the 1940s and 1950s. Southern Whispers Restaurant, located on Nelson Street, was a hot spot on the chitlin' circuit. Record companies looking for musical talent sought it on Nelson Street. Nelson was to Greeville what Beale Street was to Memphis. Greenville is also the home of Doe's Eat Place, a culinary icon known for hot tamales, steaks and traditional Italian cuisine.